Coller Institute of Venture at Tel Aviv University Introduction
 | Issue 3 of the Coller Venture Review looks at one of the more difficult kinds of innovative ventures: Deep Innovation. We define Deep Innovation as inventions that are enabled by basic research or a scientific breakthrough. Unlike what we see in the ubiquitous digital/internet/cyber startups, these usually entail substantial resources (US$5–100 million), and may take years (5–20) to materialize. Notable examples can be found in the sectors of:
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Because of the sheer size of the required effort, these innovations are notoriously difficult to bring to commercial success. The oft-used metaphor is “crossing the valley of death,” that gulf between the research laboratory and industrial application that neither academia nor industry may have the will or patience to traverse.
The ten articles in this issue examine this theme from many angles, in domains from Nanotechnology to Food Tech and from Pharma to Materials Science. The authors come from backgrounds as diverse as academia, industry, and venture capital. Between them they share success stories and lessons learned, which will inform and enlighten you as you consider deep innovation in any field of science and technology.
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Contents
 | Deep Innovation: Solving Humanity’s Big Problems Needs More CommitmentAn overview by Prof. Yesha Sivan and Dr. Robyn Klingler-Vidra |
 | Deep Innovation a la Tau Nanotech CenterAn Institutional Case Study by Prof. Yael Hanein Multi-disciplinary approach that strives for business leaps |
 | Deep Innovation in the Medical Domain a la Boston’s CIMITAn Institutional Case Study by Prof. Steven C. Schachter et al. Crossing the chasm from academia to industry |
 | Deep Innovation and Brain VenturesA Domain Case Study by Dr. Dana Bar-On Advancing solutions for debilitating conditions |
 | Deep Innovation and Pharmaceutical VenturesA Domain Case Study by Ram Waisbourd Crossing the Valley of Death |
 | Deep Innovation with Graphene TechnologiesA Technology Case Study by Prof. Daniela Baglieri et al. Recombinant capabilities and patent portfolio strategies |
 | Deep Innovation in Water VenturesA Domain Case Study by Roy Wiesner Big opportunities and challenges |
 | Deep Innovation in Food VenturesA Domain Case Study by Niccolo Manzoni Feed humanity more, and healthier |
 | Deep Innovation with Irrigation TechnologiesA Technology Case Study by Dr. Yoav Zeif Netafim – growing more with less |
 | The Challenges of Deep Innovation: From American Academia to the MarketplaceA Policy Case Study by Prof. Zeev Rosenzweig and Melissa Muth How the U.S. enables small- and medium-sized enterprises |